[Ibogaine] 18-MC Clinical trials.

Edward W. edwardw at mtciep.com
Sun Dec 15 11:46:17 CST 2013


Great detail as usual, thanks for the info Chris.

Edward W.

On 12/15/2013 10:29 AM, Chris Jenks wrote:
>
>   Dear Jim,
>
>   I know I'm not the only person who has tried to develop iboga 
> extraction techniques, but as far as I know there is really very 
> little variety available in terms of iboga products, as aside from 
> whatever hospitals Bob Sisko elects to sell his Voacanga-derived 
> ibogaine hydrochloride to, the products available to the rest of us are:
>
>   Iboga root bark
>   Iboga Total Alkaloid (TA)
>   Iboga Purified Total Alkaloid hydrochloride (PTA HCl)
>
>   The last two terms above (TA and PTA) are from my extraction 
> procedure published in 2002 
> (http://puzzlepiece.org/ibogaine/literature/jenks2002.pdf). If anyone 
> knows of a fundamentally different procedure being used to deliver 
> iboga products to the current market I would like to know about it. As 
> far as I know, everything people have been taking so far has been 
> produced using this basic procedure.
>
>   TA is a brown powder of alkaloid base which contains 30% to 50% 
> active iboga alkaloids, namely ibogaine, ibogaline and ibogamine. 
> There is also a little voacangine which can make people feel ill if 
> taken in large amounts, but I'm not sure anyone would take enough TA 
> to get negative effects from the voacangine. The TA contains all the 
> active alkaloids, and voacangine, from the bark in a similar ratio, so 
> the effects of TA should be similar to those of root bark.
>
>   When TA is refined into PTA HCl, most of the voacangine is removed, 
> and the ratio of ibogaline to ibogamine increases, although their 
> absolute percentage decreases. PTA HCl seems to be almost entirely 
> composed of ibogaine, with the latest analysis giving a composition of 
> around 89% ibogaine, 9% ibogaline and 2% ibogamine as the identifiable 
> components of PTA. So the impression Bob Sisko gave at his recent 
> (http://puzzlepiece.org/ibogaine/conference_2010/sisko_presentation.flv, 
> http://puzzlepiece.org/ibogaine/gita_conference_2012/bob_sisko.pdf - 
> this link has been broken for the last year, I just fixed it thanks to 
> this email) conference presentations, that the properties of the iboga 
> alkaloids besides ibogaine are a big unknown, was overstated to some 
> extent. Ibogaline is known to be psychoactive in humans and ibogamine 
> is known to be antiaddictive in animals, and both are very similar to 
> ibogaine in structure, so there is no reason I know of to conclude 
> that PTA HCl is pharmacologically inferior to pure ibogaine HCl.
>
>   This is not to say that all iboga products on the market are as safe 
> as pure iboga bark, TA, PTA or ibogaine. Processing and storage of 
> these products can lead to air oxidation of the alkaloids, producing 
> new compounds which may have pharmacological properties completely 
> unlike those of ibogaine. I suspect that some such substance may 
> account for additional nausea caused by some iboga products, and I 
> hope someday that it can be identified and screened. Furthermore, the 
> declining natural population and high value of iboga has led to root 
> shipments containing other species of plant and other adulterants 
> which can contaminate the iboga products dervived from them with 
> unlimited possible substances. The solutions I see being developed for 
> this problem include the sustainable cultivation of iboga, the use of 
> Voacanga species, and analysis services for iboga products.
>
>   Yours,
>
>     Chris
>
> On Sat, 14 Dec 2013, Jim Hadey3 wrote:
>



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