[Ibogaine] 18-MC Clinical trials.
edwardw at mtciep.com
Sun Dec 15 11:46:17 CST 2013
Great detail as usual, thanks for the info Chris.
On 12/15/2013 10:29 AM, Chris Jenks wrote:
> Dear Jim,
> I know I'm not the only person who has tried to develop iboga
> extraction techniques, but as far as I know there is really very
> little variety available in terms of iboga products, as aside from
> whatever hospitals Bob Sisko elects to sell his Voacanga-derived
> ibogaine hydrochloride to, the products available to the rest of us are:
> Iboga root bark
> Iboga Total Alkaloid (TA)
> Iboga Purified Total Alkaloid hydrochloride (PTA HCl)
> The last two terms above (TA and PTA) are from my extraction
> procedure published in 2002
> (http://puzzlepiece.org/ibogaine/literature/jenks2002.pdf). If anyone
> knows of a fundamentally different procedure being used to deliver
> iboga products to the current market I would like to know about it. As
> far as I know, everything people have been taking so far has been
> produced using this basic procedure.
> TA is a brown powder of alkaloid base which contains 30% to 50%
> active iboga alkaloids, namely ibogaine, ibogaline and ibogamine.
> There is also a little voacangine which can make people feel ill if
> taken in large amounts, but I'm not sure anyone would take enough TA
> to get negative effects from the voacangine. The TA contains all the
> active alkaloids, and voacangine, from the bark in a similar ratio, so
> the effects of TA should be similar to those of root bark.
> When TA is refined into PTA HCl, most of the voacangine is removed,
> and the ratio of ibogaline to ibogamine increases, although their
> absolute percentage decreases. PTA HCl seems to be almost entirely
> composed of ibogaine, with the latest analysis giving a composition of
> around 89% ibogaine, 9% ibogaline and 2% ibogamine as the identifiable
> components of PTA. So the impression Bob Sisko gave at his recent
> http://puzzlepiece.org/ibogaine/gita_conference_2012/bob_sisko.pdf -
> this link has been broken for the last year, I just fixed it thanks to
> this email) conference presentations, that the properties of the iboga
> alkaloids besides ibogaine are a big unknown, was overstated to some
> extent. Ibogaline is known to be psychoactive in humans and ibogamine
> is known to be antiaddictive in animals, and both are very similar to
> ibogaine in structure, so there is no reason I know of to conclude
> that PTA HCl is pharmacologically inferior to pure ibogaine HCl.
> This is not to say that all iboga products on the market are as safe
> as pure iboga bark, TA, PTA or ibogaine. Processing and storage of
> these products can lead to air oxidation of the alkaloids, producing
> new compounds which may have pharmacological properties completely
> unlike those of ibogaine. I suspect that some such substance may
> account for additional nausea caused by some iboga products, and I
> hope someday that it can be identified and screened. Furthermore, the
> declining natural population and high value of iboga has led to root
> shipments containing other species of plant and other adulterants
> which can contaminate the iboga products dervived from them with
> unlimited possible substances. The solutions I see being developed for
> this problem include the sustainable cultivation of iboga, the use of
> Voacanga species, and analysis services for iboga products.
> On Sat, 14 Dec 2013, Jim Hadey3 wrote:
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