[Ibogaine] Latest Iboga Extraction Procedure

Chris Jenks chris at jenks.us
Thu Dec 6 17:00:30 EST 2012

   I wanted to make sure to put the latest refinements into a procedure to 
prevent, if possible, any loss of ibogaine:

   Powder the root or root bark and weigh one kilogram of it into two 20 
Liter plastic buckets, each with 500 grams. To the first bucket add 2.5 
Liters of water and 20 mL of concentrated HCl and stir occasionally for 
one hour. Filter this mixture through a new pillow case into the second 
bucket and add the same amounts of water and acid again to the first 
bucket. After another hour of occasional stirring of both buckets, filter 
the extract from the second bucket through the pillow case into a third 
bucket, filter the mixture in the first bucket into the second bucket, and 
add fresh water and acid to the first bucket. The extract in the third 
bucket is basified using 106 mL of 10% sodium hydroxide solution and 
filtered through large, pre-weighed coffee filter paper. The same sequence 
for the two buckets of root is repeated until water and acid have been 
added to the first bucket nine times. The extract from the first bucket is 
used to extract the contents of the second one last time, and then this 
extract is filtered, made basic and filtered like the previous eight. The 
coffee filter papers are rinsed with water and laid on dry towels in 
streams of warm air to dry. The dried TA is weighed, ground and optionally 
sifted and reground.

   If new pillow cases were used, no further processing of the TA should be 
necessary since the fabric will not have degraded from exposure to the 
HCl. Otherwise, to make "super TA" which lacks root pulp, the TA can be 
redissolved in acid, filtered and precipitated with base. To do this, 
place 50 grams of powdered TA and a stir bar into a 1 Liter Erlenmeyer 
flask and add 400 mL of water and 4 mL of concentrated HCl. Stir the flask 
for an hour and filter the mixture through paper. Return the solid from 
the filter to the flask and add the same amounts of water and acid a 
second and third time, stirring and filtering in between. Basify the 
combined filtrates with 63 mL of 10% sodium hydroxide solution and filter, 
rinse and dry the precipitated super TA through pre-weighed laboratory 
filter paper. This super TA should have nearly the potency of PTA HCl.

   To prepare PTA HCl, place 50 grams of TA into a funnel with a 
pre-weighed filter paper. Extract the TA with 750 mL of acetone, stirring 
occasionally. Put the covered flask of filtrate in the refrigerator and 
place the drained filter in a stream of warm air until all the smell of 
acetone is gone and the paper loses no further weight, and determine the 
weight lost by the TA due to extraction. Multiply this weight loss in 
grams by 3/7 to determine the number of milliliters of concentrated HCl to 
add to the filtrate. Add this with stirring over several minutes dropwise. 
If a fluffy material separates during this addition process (an oily, 
non-solid precipitate is suspected to be caused by the presence of root 
pulp in the TA or a poor quality of root material), stop the stirring 
after half of the planned acid has been added, let the fluff settle and 
decant the solution from the fluff. Rinse the fluff with 50 mL of fresh 
acetone and add this to the solution before proceeding with the acid 
addition. Once all the acid has been added, or the mixture has become 
acidic, let the flask sit in the refrigerator overnight before filtering 
and drying the PTA HCl on pre-weighed laboratory filter paper. Any solid 
which deposits on the sides of the flask can be most effectively removed 
by scraping it with a spoon into a small amount of fresh acetone and 
rinsed into the wet PTA HCl filter before drying.

   The acetone filtrate that the PTA HCl was removed from is placed in a 2
L round bottom flask with a stir bar and distilled until about 10% of the
original volume is left. The remaining mixture is poured into a glass
casserole dish and set outside in a stream of warm air until all the
acetone has evaporated, leaving a non-mobile brown oil. This dark, syrupy
residue is dissolved in 500 mL of water from both the distillation flask
and the casserole dish and filtered through laboratory filter paper. The
filtered solution is then made basic with 50 mL of 30% ammonia, mixed
thoroughly, and filtered through pre-weighed laboratory filter paper. The
light yellow solid dries into light chalky pieces which can be stored
indefinitely in the freezer. The acetone distillate is redistilled with
stirring from 5 grams of sodium hydroxide pellets to remove traces of
hydrochloric acid, giving wet acetone suitable for cleaning purposes.



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