[Ibogaine] New treatment for meth/cocaine/alcohol addiction
sisterwind at verizon.net
Tue Mar 22 14:09:03 EDT 2011
flumaznill needs to be given while on a heart monitor also.
--- On Tue, 3/22/11, Chris Jenks <chris at jenks.us> wrote:
From: Chris Jenks <chris at jenks.us>
Subject: Re: [Ibogaine] New treatment for meth/cocaine/alcohol addiction
To: "The Ibogaine List" <ibogaine at mindvox.com>
Date: Tuesday, March 22, 2011, 1:54 PM
On Mon, 21 Mar 2011, Jim Hadey wrote:
> The three chemicals [in Prometa] are: Flumazenil,
> Gabapentin and hydroxyzine.
According to wikipedia, Flumazenil is a very short acting benzodiazepine antagonist, with a benzodiazepine structure. It is given by intravenous injection, usually for the purpose of counteracting the effect of sedating drugs as in a case of overdose.
Gabapentin is a GABA derivative which seems to act on receptors besides GABA. Wikipedia says:
"Gabapentin (administered orally) is one of two medications (the other being flumazenil, which is administered intravenously) used in the expensive Prometa Treatment Protocol for methamphetamine, cocaine and alcohol addiction. Gabapentin is administered at a dosage of 1200 mg taken at bedtime for 40 - 60 days. Though the combination of flumazenil infusions and gabapentin tablets is a licensed treatment, there is no prohibition against a physician prescribing gabapentin outside the Prometa protocol. There have been reports by methamphetamine addicts that gabapentin alone in doses of 1200 mg at bedtime taken for 40 - 60 days has been effective in reducing cravings or desire to use methamphetamine. It also attenuates the severity of withdrawal symptoms experienced by those physically dependent on opioid analgesics, such as heroin, morphine, and oxycodone. One study also demonstrates a significant reduction in the severity of benzodiazepine withdrawal
Under Precautions, wikipedia says:
"Gabapentin should not be discontinued abruptly after long term use. Abrupt or over rapid withdrawal may provoke a withdrawal syndrome similar to alcohol or benzodiazepine withdrawal."
The use of Flumazenil should prevent this withdrawal by preventing tolerance at the GABA receptor by Gabapentin.
According to wikipedia, hydroxyzine is a first-generation antihistamine and anxiolytic, and structurally it is a racemic mixture of a benzyl piperazine derivative. It boosts the action of opioids. Under Animal Research, this antihistamine seems to help rats to recover from "learned helplessness". Since addiction can be seen as an instance of learned helplessness, this obscure drug may be the key to the mixture's action.
All three of these drugs seem reasonably easy to aquire, though I'm not sure how the Flumazenil is meant to be administered if it is really given daily with the Gabapentin.
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