[Ibogaine] MK 801??

j0n at just-say-know.org j0n at just-say-know.org
Wed Jul 16 10:12:38 EDT 2008


hey dana, if you could send along that attachment, that'd be highly groovy.

> Dana-
>
> What is being blocked is the rat's ability to discriminate PCP in the
> presence of classical hallucinogen 5-HT2A agonists. This is because
> the 5-HT2A cue tends to be well-recognized by rats, which is why
> discrimination is a good paradigm for demonstrating classical
> hallucinogen effects, which are mediated by the 5-HT2A agonist action.
>
> The article does NOT mean that the psychoactive effective of PCP is
> opposed by LSD. It just means that LSD is very distinctive and
> recognizable to a rat, even when the rat is dusted.
>
> The 5-HT2A stimulus is nonessential for ibogaine, meaning that
> animals trained to respond to 5-HT2A agonists tend to provide a
> similar response to ibogaine, but if you block 5-HT2A with animals
> trained to respond to ibogaine, they can still recognize ibogaine.
> The ibogaine stimulus appears to be mediated by sigma2 effects.
>
> For classical hallucinogens, the 5-HT2A cue mediates discriminability
> and correlates well with psychoactive effects. For ibogaine,
> discrimination does not tell you much about ibogaine's ant-addictive
> effects. Discrimination works better for LSD than ibogaine.
>
> The paper you referenced and a review on ibogaine and drug
> discrimination are attached.
> -KA
>
>
> I can send the attachment to anyone who's interested.
>
> Dana/cnw
>
>
> On Jul 10, 2008, at 4:39 AM, Warren Theriot wrote:
>
>> Guess what happens when you take LSD with NMDA antagonists:
>>
>> http://www.erowid.org/references/refs_view.php?ID=7077
>>
>> Warren
>>
>
>
>   -=[) ::::::: MindVox | Ibogaine | List Commands ::::::: (]=-
> (][%]  :: http://mindvox.com/mailman/listinfo/ibogaine ::  [%][)
>   -=[) :::: Change Account Settings :: [Un]Subscribe :::: (]=-
>





More information about the Ibogaine mailing list