[Ibogaine] MK 801??

Dana Beal dana at phantom.com
Tue Jul 15 21:21:28 EDT 2008


What is being blocked is the rat's ability to discriminate PCP in the  
presence of classical hallucinogen 5-HT2A agonists. This is because  
the 5-HT2A cue tends to be well-recognized by rats, which is why  
discrimination is a good paradigm for demonstrating classical  
hallucinogen effects, which are mediated by the 5-HT2A agonist action.

The article does NOT mean that the psychoactive effective of PCP is  
opposed by LSD. It just means that LSD is very distinctive and  
recognizable to a rat, even when the rat is dusted.

The 5-HT2A stimulus is nonessential for ibogaine, meaning that  
animals trained to respond to 5-HT2A agonists tend to provide a  
similar response to ibogaine, but if you block 5-HT2A with animals  
trained to respond to ibogaine, they can still recognize ibogaine.  
The ibogaine stimulus appears to be mediated by sigma2 effects.

For classical hallucinogens, the 5-HT2A cue mediates discriminability  
and correlates well with psychoactive effects. For ibogaine,  
discrimination does not tell you much about ibogaine's ant-addictive  
effects. Discrimination works better for LSD than ibogaine.

The paper you referenced and a review on ibogaine and drug  
discrimination are attached.

I can send the attachment to anyone who's interested.


On Jul 10, 2008, at 4:39 AM, Warren Theriot wrote:

> Guess what happens when you take LSD with NMDA antagonists:
> http://www.erowid.org/references/refs_view.php?ID=7077
> Warren

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