[Ibogaine] chronic pain thing

Sara Glatt sara119 at xs4all.nl
Sat Feb 16 07:53:00 EST 2008


and the above link if you like checking out may give you a little more hope.

 perhaps there's more going on with my depression/ups/downs issues than
> simply bad choices and/or addictive tendencies. Always enjoy finding
> something that helps me feel that perhaps I'm not such a total dick after
> all, or at least gives me hope that's the case.
> http://news.yahoo.com/s/hsn/20080209/hl_hsn/chronicpainharmsbrainswiring
> FRIDAY, Feb. 8 (HealthDay News) -- Chronic pain can disrupt brain function
> and cause problems such as disturbed sleep, depression, anxiety and
> difficulty making simple decisions, a U.S. study finds.
> Researchers at Northwestern University's Feinberg School of Medicine in
> Chicago used functional MRI to scan brain activity in people with chronic
> low back pain while they tracked a moving bar on a computer screen. They
> did the same thing with a control group of people with no pain.
> In those with no pain, the brain regions displayed a state of equilibrium.
> When one region was active, the other regions calmed down. But in people
> with chronic pain, the front region of the cortex mostly associated with
> emotion "never shuts up," study author Dante Chialvo, an associate
> research professor of physiology, said in a prepared statement.
> This region remains highly active, which wears out neurons and alters
> their connections to each other. This constant firing of neurons could
> cause permanent damage.
> "We know when neurons fire too much they may change their connections with
> other neurons or even die, because they can't sustain high activity for so
> long," Chialvo said.
> "If you are a chronic pain patient, you have pain 24 hours a day, seven
> days a week, every minute of your life. That permanent perception of pain
> in your brain makes these areas in your brain continuously active. This
> continuous dysfunction in the equilibrium of the brain can change the
> wiring forever and could hurt the brain," Chialvo explained.
> These changes "may make it harder for you to make a decision or be in a
> good mood to get up in the morning. It could be that pain produces
> depression and the other reported abnormalities, because it disturbs the
> balance of the brain as a whole," he said.
> The study was published in the Feb. 6 issue of The Journal of
> Neuroscience.
> Chialvo said the findings show that, along with finding new ways to treat
> pain%2

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