Role of D1/D2 dopamine and NMDA receptors in morphine tolerance and dependence
dana at phantom.com
Wed Jun 27 18:08:35 EDT 2007
Title Role of D1/D2 dopamine and
N-methyl-D-aspartate (NMDA) receptors in morphine
tolerance and dependence in mice.
Citation help Eur Neuropsychopharmacol. 1995
Authors help Verma A, Kulkarni SK.
Institution help Department of Pharmaceutical
Sciences, Panjab University, Chandigarh, India.
PubMed® ID help 7549459 [PubMed]
Review Status help Unreviewed. Request curation.
Abstract help Chronic treatment with the dopamine
(DA) agonist B-HT 920 (0.25-1 mg/kg) or bromocriptine
(1 mg/kg) followed by morphine (10 mg/kg) on days 1-9
prevented the development of tolerance to the
antinociceptive effect of morphine as measured by the
tail-flick test in mice, but failed to suppress the
development of morphine dependence as assessed by
naloxone (2 mg/kg)-precipitated withdrawal jumps on
day 10 of testing. Repeated administration of SKF
38393 (5 mg/kg) followed by morphine for 9 days
significantly reduced naloxone-precipitated jumps on
day 10 but failed to produce any significant change in
tail-flick latency from the saline-pretreated group of
mice on days 9 and 10 of testing. Repeated
administration of B-HT 920 or bromocriptine enhanced
the ability of MK-801 to attenuate the development of
morphine tolerance and dependence while SKF 38393
failed to do so. The above data suggest a preferential
role of D2 DA receptors in morphine tolerance and D1
receptors in the development of morphine dependence.
D2 DA receptor stimulation may also play an important
role in enhancing the effectiveness of MK-801 in the
treatment of opiate tolerance and dependence.
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