[Ibogaine] ibogaine research in Slovenia

kirk captkirk at kol.co.nz
Sun Oct 29 04:00:52 EST 2006

There’s so much more to this stuff than anti-addiction……… I felt it dammit!!

Just have to find someone to research it with……………..

Ah well…….

One day roger fink



From: HSLotsof at aol.com [mailto:HSLotsof at aol.com] 
Sent: Sunday, 29 October 2006 6:56 p.m.
To: ibogaine at mindvox.com
Subject: [Ibogaine] ibogaine research in Slovenia


Eur J Pharmacol. 2006 Sep 16; [Epub ahead of print]
Ibogaine affects brain energy metabolism.
     •     Paskulin R, Jamnik P, Zivin M, Raspor P, Strukelj B.
OMI Institute, Trnovska 8, Ljubljana, Slovenia.
Ibogaine is an indole alkaloid present in the root of the plant Tabernanthe
iboga. It is known to attenuate abstinence syndrome in animal models of drug
addiction. Since the anti-addiction effect lasts longer than the presence of
ibogaine in the body, some profound metabolic changes are expected. The aim
of this study was to investigate the effect of ibogaine on protein
expression in rat brains. Rats were treated with ibogaine at 20 mg/kg body
weight i.p. and subsequently examined at 24 and 72 h. Proteins were
extracted from whole brain and separated by two-dimensional (2-D)
electrophoresis. Individual proteins were identified by matrix-assisted
laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS).
Enzymes of glycolysis and tricarboxylic acid (TCA) cycle namely
glyceraldehyde-3-phosphate dehydrogenase, aldolase A, pyruvate kinase and
malate dehydrogenase were induced. The results suggest that the remedial
effect of ibogaine could be mediated by the change in energy availability.
Since energy dissipating detoxification and reversion of tolerance to
different drugs of abuse requires underlying functional and structural
changes in the cell, higher metabolic turnover would be favourable.
Understanding the pharmacodynamics of anti-addiction drugs highlights the
subcellular aspects of addiction diseases, in addition to neurological and
psychological perspectives.
PMID: 17054944 [PubMed - as supplied by publisher]


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