[Ibogaine] ibogaine research in Slovenia
marko at phantom.com
Sun Oct 29 07:02:12 EST 2006
There is another article on OMI research named "Influence of ibogaine on
expression of genes". It's about the same subject, it seems, but words
are put together in such a manner one understands easyer ;-)
There are more articles in Slovene language on OMI site.
OMI is linked from http://sacrament.kibla.si/
HSLotsof at aol.com wrote:
> _Eur J Pharmacol._ 2006 Sep 16; [Epub ahead of print]
> *Ibogaine affects brain energy metabolism.
> ** • Paskulin R*, *Jamnik P*, *Zivin M*, *Raspor P*, *Strukelj B*.
> OMI Institute, Trnovska 8, Ljubljana, Slovenia.
> Ibogaine is an indole alkaloid present in the root of the plant
> Tabernanthe iboga. It is known to attenuate abstinence syndrome in
> animal models of drug addiction. Since the anti-addiction effect lasts
> longer than the presence of ibogaine in the body, some profound
> metabolic changes are expected. The aim of this study was to
> investigate the effect of ibogaine on protein expression in rat
> brains. Rats were treated with ibogaine at 20 mg/kg body weight i.p.
> and subsequently examined at 24 and 72 h. Proteins were extracted from
> whole brain and separated by two-dimensional (2-D) electrophoresis.
> Individual proteins were identified by matrix-assisted laser
> desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS).
> Enzymes of glycolysis and tricarboxylic acid (TCA) cycle namely
> glyceraldehyde-3-phosphate dehydrogenase, aldolase A, pyruvate kinase
> and malate dehydrogenase were induced. The results suggest that the
> remedial effect of ibogaine could be mediated by the change in energy
> availability. Since energy dissipating detoxification and reversion of
> tolerance to different drugs of abuse requires underlying functional
> and structural changes in the cell, higher metabolic turnover would be
> favourable. Understanding the pharmacodynamics of anti-addiction drugs
> highlights the subcellular aspects of addiction diseases, in addition
> to neurological and psychological perspectives.
> PMID: 17054944 [PubMed - as supplied by publisher]
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