ibogaine research in Slovenia

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Sun Oct 29 01:55:50 EDT 2006


Eur J Pharmacol. 2006 Sep 16; [Epub ahead of print]
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Ibogaine affects brain energy metabolism.
     •     Paskulin R, Jamnik P, Zivin M, Raspor P, Strukelj B.
OMI Institute, Trnovska 8, Ljubljana, Slovenia.
Ibogaine is an indole alkaloid present in the root of the plant Tabernanthe 
iboga. It is known to attenuate abstinence syndrome in animal models of drug 
addiction. Since the anti-addiction effect lasts longer than the presence of 
ibogaine in the body, some profound metabolic changes are expected. The aim of 
this study was to investigate the effect of ibogaine on protein expression in 
rat brains. Rats were treated with ibogaine at 20 mg/kg body weight i.p. and 
subsequently examined at 24 and 72 h. Proteins were extracted from whole brain 
and separated by two-dimensional (2-D) electrophoresis. Individual proteins were 
identified by matrix-assisted laser desorption/ionization-time of flight mass 
spectrometry (MALDI-TOF MS). Enzymes of glycolysis and tricarboxylic acid 
(TCA) cycle namely glyceraldehyde-3-phosphate dehydrogenase, aldolase A, pyruvate 
kinase and malate dehydrogenase were induced. The results suggest that the 
remedial effect of ibogaine could be mediated by the change in energy 
availability. Since energy dissipating detoxification and reversion of tolerance to 
different drugs of abuse requires underlying functional and structural changes in 
the cell, higher metabolic turnover would be favourable. Understanding the 
pharmacodynamics of anti-addiction drugs highlights the subcellular aspects of 
addiction diseases, in addition to neurological and psychological perspectives.
PMID: 17054944 [PubMed - as supplied by publisher]
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