[Ibogaine] Fw: [NEWSROOM-L] Nicotine fight aims at brain receptors

CallieMimosa at aol.com CallieMimosa at aol.com
Wed Jun 28 18:03:16 EDT 2006

Sure wish they would come up with something that would make quitting more  of 
a reality! The walls in our house need painting due to smoke stains! Really  
Charlie needs to quit so he can have desperately needed plastic surgery on  2 
pressure sores! His physician will not do surgery until he has been smoke 
free  for a month. Says that probability of him not healing is very great if he 
has  surgery while he is a smoker.
It is almost impossible to quit tho. 
If we quit it will be one of the hardest things I have ever  accomplished!
In a message dated 6/28/2006 4:52:39 P.M. Central Standard Time,  
ptpeet at nyc.rr.com writes:

----- Original Message ----- 
From: "mcoady"  <mcoady at COMCAST.NET>
Sent: Monday, June 26, 2006 10:52  AM
Subject: [NEWSROOM-L] Nicotine fight aims at brain  receptors

Nicotine fight aims at brain  receptors
Vaccine,  drug in development
By Carey Goldberg, Globe Staff  |  June 26,  2006

Smokers are about to get some radically different methods to help  them quit, 
based in large part on scientists' progress in attacking  nicotine addiction 
where it happens: in the smoker's brain.

Last  week, patients in a clinical trial at Massachusetts General Hospital  
received their first doses of an experimental vaccine that keeps most  
nicotine from entering the brain. By late summer, Pfizer expects to begin  
selling a new pill that partially blocks a receptor -- a type of on-off  
switch -- in the brain that seems to be the central culprit in smoking  

Also on its way, researchers say, is an experimental  drug that targets 
receptors first discovered in research on marijuana and  the ``munchies." By 
damping down areas of the brain involved in craving,  this drug may help 
smokers quit without gaining much weight, initial  studies suggest.

For the first time in 10 years, ``we have completely  new approaches for 
smoking cessation," and there is hope that the new  drugs, because they 
better target the brain's addiction response, could  prove more effective 
than current treatments," said Dr. Nancy Rigotti,  director of Mass. 
General's Tobacco Research and Treatment Center. She  cautioned, though, that 
none of the new treatments ``is a magic  bullet."

New tools to help quit smoking are desperately needed, federal  health 
authorities say. Among the 44 million Americans who smoke, about 70  percent 
would like to quit and 40 percent really try. But in a given year,  fewer 
than 5 percent of would-be quitters actually succeed, a National  Institutes 
of Health panel said last week.

Current drug treatments  are moderately effective, on average doubling the 
success rate of smokers  trying to quit compared with those who attempt to 
break their addiction  without any pharmaceutical assistance, said Rigotti.

The arsenal for  quitters includes various types of counseling, nicotine 
replacement in  forms ranging from patches to lozenges to inhalers, and 
Zyban, an  antidepressant found to help smokers kick the habit.

None of these has  helped Tim Campbell, 44, of Ipswich. Despite endless 
urging from his wife  and six children, and a half-dozen attempts to quit 
that have included  Zyban, nicotine gum, the patch, and hypnosis, he just 
cannot beat his  pack-a-day habit. In 30 years of smoking, the longest he has 
ever stayed  away from cigarettes was about a month. Cigarettes are the first 
thing on  his mind every morning; he smoked even during a cancer walk with 
his  sister.

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