Fw: 'left', 'right' and mixed methadone ... regular mixed methadone just as good.

Preston Peet ptpeet at nyc.rr.com
Wed Nov 2 12:24:51 EST 2005

Peace and love,
Preston Peet

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----- Original Message ----- 
From: Andrew Byrne 
To: ajbyrne at ozemail.com.au 
Sent: Monday, October 31, 2005 10:55 PM
Subject: 'left', 'right' and mixed methadone ... regular mixed methadone just as good.

The effects of racemic D,L-methadone and L-methadone in substituted patients - a randomized controlled study. Verthein U, Ullmann R et al.  Drug and Alcohol Dependence (2005) 80; 2: 267-271


Dear Colleagues, 


This interesting and definitive study from Hamburg informs us that pure 'levomethadone' and racemic methadone are clinically equivalent in the expected ratio of 1:2 with no significant difference in withdrawal symptoms or other clinical aspects of maintenance treatment.  The pure enantiomer is more expensive and thus should probably be phased out in Germany, the only country where it had widespread use.  


Despite no real evidence, some have speculated that certain methadone side effects might be due by the inactive L or 'dextro' component.  This careful, cross-over, randomised trial with 75 subjects has only found mild, transient differences in sudden experimental substitutions of medication.  These did not reach significance and confirm what was done by Judson in 1976.  


Comments from Andrew Byrne ..



   Dr Andrew Byrne MB BS (Syd) FAChAM (RACP)

   Dependency Medicine,

   75 Redfern Street, Redfern,

   New South Wales, 2016, Australia

   Email - ajbyrneATozemail.com.au

   Tel (61 - 2) 9319 5524  Fax 9318 0631




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