Huge amount of ibogaine press

Vector Vector vector620022002 at
Fri Jan 21 16:17:22 EST 2005

New mechanism of action?

These are the first 3 hits, there are alot more then this and not all
of them are the same article, they're the same story re written.

You can find them on yahoo or google in the News section


African herb yields its anti-addiction secret

22 January 2005

>From New Scientist Print Edition. Subscribe and get 4 free issues.

Bob Holmes

More Health Stories

African herb yields its anti-addiction secret

Explore: health

THE secret of an African herb that helps drug addicts and alcoholics
the habit has been discovered. The finding could lead to safer and more
effective medications for treating addiction.

Since the 1960s, many addicts have reported that even a single dose of
ibogaine, a hallucinogenic alkaloid extracted from the root of an
shrub, helps them kick their habit by reducing their cravings for
And there is hard evidence to back these claims, as well. However,
troubling side effects - including heart problems and several deaths -
have kept ibogaine from being widely accepted as a medical treatment.
Instead, a few researchers have begun searching for ways to deliver
ibogaine's benefits without its risks (New Scientist, 26 April 2003, p

A few previous studies have suggested that becoming addicted to a
substance lowers the production of a nerve growth factor called glial
cell-line derived neurotrophic factor, or GDNF. So Dorit Ron's team at
University of California, San Francisco, decided to test whether
affects GDNF levels in the brain.

In rats injected with ibogaine, the researchers found that production
GDNF increased in a region of the brain called the ventral tegmental
What's more, injecting either ibogaine or GDNF itself directly into
brain area decreased alcohol cravings in addicted rats, whereas
anti-GDNF antibodies eliminated any beneficial effect of ibogaine. The
results appear in The Journal of Neuroscience.

"The paper looks very solid," says Stanley Glick, a neuropharmacologist
Albany Medical Center in New York, who has studied ibogaine for many   

years. "They may indeed be on to a major finding." However, both Glick
Ron point out that boosting GDNF may be only one of several mechanisms
which ibogaine acts to ease addiction.

A synthetic ibogaine compound, 18-methoxycoronaridine, which Glick has
shown can help addicts with fewer harmful side effects than ibogaine,
also work by controlling GDNF levels. In preliminary studies with
nerve cells, Ron's team found that 18-MC also raises GDNF levels.

But the team is not pursuing the ibogaine approach. Instead, Ron thinks
is time to narrow her focus. "Our idea now is to move away from
and concentrate on GDNF," she says. Her team plans to look for ways to
stimulate GDNF without side effects.

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