UK ibogaine atticle BBC
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HSLotsof at aol.com
Wed Jan 19 09:14:29 EST 2005
1960s drug 'alcoholism cure hope'
A hallucinogenic drug popular in the 1960s could help scientists find a
medical treatment for alcoholism, US researchers believe.
A University of California team said ibogaine blocked alcohol cravings in
rats by boosting a brain protein.
It was already thought it could combat addiction, but scientists have been
wary as the drug is also toxic.
It is hoped a treatment which works in the same way as ibogaine but without
the side effects could be developed.
It causes hallucinations as well a feeling of lightness
Effects strongest after two hours
Users can experience a deep dreamy trance-like state for long periods
Used as a recreational drug
Also taken by heroin and cocaine addicts to beat cravings
In the UK, about 2.9 million adults - 7% of the population - are alcohol
Alcohol misuse is linked to 22,000 deaths a year and costs the economy £20bn
a year in lost production and treatment.
People who misuse alcohol tend to be treated through counselling, although
there are a few drugs available which are sometimes used in conjunction with
The research team believes the findings, published in the Journal of
Neuroscience, could lead to a change in approach to treating alcohol addiction.
Report co-author Patricia Janak said they found the drug worked by increasing
the level of the GDNF protein in the brain.
Previously, scientists were aware the drug may reduce dependency but did not
fully understand how it worked.
She said the team induced the rats to consume alcohol and found once they
were injected with ibogaine their GDNF levels increased and they reduced their
There is a link to craving in the brain and if we can influence that it
is feasible to develop a drug treatment
Dr Bruce Ritson
She said the effect may stop people "falling off the wagon" as when rats were
denied alcohol for two weeks those given ibogaine had a much lower craving
when offered alcohol.
"The discovery that ibogaine reduced binge drinking after a period of
abstinence was an exiting finding for us because this is the type of behaviour in
alcoholics for which very few effective drugs exist."
While the drug remains unlicensed in the UK and much of the rest of the
world, it is used to treat addiction in several private clinics in the Caribbean
But Alcohol Concern said the findings should be treated with caution.
A spokeswoman said: "This type of study could prove useful in the long term
to shed light on the relationship between the brain and alcohol intake.
"However, very little can be drawn from a single animal-based study at this
A further note of caution was added by Martin Plant, professor of addiction
studies at the University of the West of England, who said: "People become
addicted to alcohol for many different reason. The idea that taking tablets cures
the problem is naive."
Dr Bruce Ritson, of the Medical Council on Alcohol, said: "Addiction is a
complex area and I would not believe it is the whole answer."
Story from BBC NEWS:
Published: 2005/01/19 01:22:53 GMT
© BBC MMV
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