[Ibogaine] Gallo Research Center studies cause and treatment of alcohol, drug addiction
bleshins at bigpond.net.au
Thu Aug 11 23:34:43 EDT 2005
---- HSLotsof at aol.com wrote:
Since non-N-methyl-D-aspartate (NMDA) receptors
> mediate Purkinje cell excitation by climbing fibers, we hypothesized that
> 1-4-aminophenyl-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI-52466), which
> antagonizes non-NMDA receptors, may have a neuroprotective effect by blocking
> glutamatergic excitation at climbing fiber synapses. To test this hypothesis,
> rats were administered systemic ibogaine plus GYKI-52466 and the degree of
> neuronal injury was analyzed in cerebellar sections. The results indicate that
> the AMPA antagonist GYKI-52466 (10 mg/kg i.p. x 3) does not protect against
> Purkinje cell injury at the doses used. Rather, co-administration of GYKI-52466
> with ibogaine produces increased toxicity evidenced by more extensive Purkinje
> cell degeneration.
Does the above property extend to other benzodiazepines?
ie. could taking Valium with Ibogaine lead to greater brain damage?
Or am I completely off the mark here?
More information about the Ibogaine