[Ibogaine] Gallo Research Center studies cause and treatment of alcohol, drug addiction

Boris Leshinsky bleshins at bigpond.net.au
Thu Aug 11 23:34:43 EDT 2005


---- HSLotsof at aol.com wrote: 

 Since non-N-methyl-D-aspartate (NMDA) receptors 
> mediate Purkinje cell excitation by climbing fibers, we hypothesized that 
> 1-4-aminophenyl-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI-52466), which 
> antagonizes non-NMDA receptors, may have a neuroprotective effect by blocking 
> glutamatergic excitation at climbing fiber synapses. To test this hypothesis, 
> rats were administered systemic ibogaine plus GYKI-52466 and the degree of 
> neuronal injury was analyzed in cerebellar sections. The results indicate that 
> the AMPA antagonist GYKI-52466 (10 mg/kg i.p. x 3) does not protect against 
> Purkinje cell injury at the doses used. Rather, co-administration of GYKI-52466 
> with ibogaine produces increased toxicity evidenced by more extensive Purkinje 
> cell degeneration.


Does the above property extend to other benzodiazepines?
ie. could taking Valium with Ibogaine lead to greater brain damage?
Or am I completely off the mark here? 

cheers
Boris




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