[ibogaine] shelf life

Gamma gammalyte9000 at yahoo.com
Thu Jan 1 15:25:11 EST 2004

Good article. 

which leads me to ask, what is the shelf life of ibogaine hcl?

should it be kept fridgerated?


out of direct light?  

inquiring minds vant to know.

- G A M M A

--- HSLotsof at aol.com wrote:
> September 9, 2002
> Try An Experiment With Your Mother-In-Law
> By Richard Altschuler
> Does the expiration date on a bottle of a medication mean anything? If a 
> bottle of Tylenol, for example, says something like "Do not use after June
> 1998," 
> and it is August 2002, should you take the Tylenol? Should you discard it?
> Can 
> you get hurt if you take it? Will it simply have lost its potency and do you 
> no good?
> In other words, are drug manufacturers being honest with us when they put an 
> expiration date on their medications, or is the practice of dating just 
> another drug industry scam, to get us to buy new medications when the old
> ones that 
> purportedly have "expired" are still perfectly good?
> These are the pressing questions I investigated after my mother-in-law 
> recently said to me, "It doesn't mean anything," when I pointed out that the
> Tylenol 
> she was about to take had "expired" 4 years and a few months ago. I was a bit
> mocking in my pronouncement -- feeling superior that I had noticed the 
> chemical corpse in her cabinet -- but she was equally adamant in her reply,
> and is 
> generally very sage about medical issues.
> So I gave her a glass of water with the purportedly "dead" drug, of which she
> took 2 capsules for a pain in the upper back. About a half hour later she 
> reported the pain seemed to have eased up a bit. I said "You could be having
> a 
> placebo effect," not wanting to simply concede she was right about the drug,
> and 
> also not actually knowing what I was talking about. I was just happy to hear 
> that her pain had eased, even before we had our evening cocktails and hot tub
> dip (we were in "Leisure World," near Laguna Beach, California, where the hot
> tub is bigger than most Manhattan apartments, and "Heaven," as generally 
> portrayed, would be raucous by comparison).
> Upon my return to NYC and high-speed connection, I immediately scoured the 
> medical databases and general literature for the answer to my question about 
> drug expiration labeling. And voila, no sooner than I could say "Screwed
> again by 
> the pharmaceutical industry," I had my answer. Here are the simple facts:
> First, the expiration date, required by law in the United States, beginning 
> in 1979, specifies only the date the manufacturer guarantees the full potency
> and safety of the drug -- it does not mean how long the drug is actually
> "good" 
> or safe to use. Second, medical authorities uniformly say it is safe to take 
> drugs past their expiration date -- no matter how "expired" the drugs 
> purportedly are. Except for possibly the rarest of exceptions, you won't get
> hurt and 
> you certainly won't get killed. A contested example of a rare exception is a 
> case of renal tubular damage purportedly caused by expired tetracycline 
> (reported by G. W. Frimpter and colleagues in JAMA, 1963;184:111). This
> outcome 
> (disputed by other scientists) was supposedly caused by a chemical
> transformation 
> of the active ingredient. Third, studies show that expired drugs may lose
> some 
> of their potency over time, from as little as 5% or less to 50% or more 
> (though usually much less than the latter). Even 10 years after the
> "expiration 
> date," most drugs have a good deal of their original potency. So wisdom
> dictates 
> that if your life does depend on an expired drug, and you must have 100% or
> so 
> of its original strength, you should probably toss it and get a refill, in 
> accordance with the cliché, "better safe than sorry." If your life does not 
> depend on an expired drug -- such as that for headache, hay fever, or
> menstrual 
> cramps -- take it and see what happens.
> One of the largest studies ever conducted that supports the above points 
> about "expired drug" labeling was done by the US military 15 years ago,
> according 
> to a feature story in the Wall Street Journal (March 29, 2000), reported by 
> Laurie P. Cohen. The military was sitting on a $1 billion stockpile of drugs
> and 
> facing the daunting process of destroying and replacing its supply every 2 to
> 3 years, so it began a testing program to see if it could extend the life of 
> its inventory. The testing, conducted by the US Food and Drug Administration 
> (FDA), ultimately covered more than 100 drugs, prescription and 
> over-the-counter. The results showed that about 90% of them were safe and
> effective as far as 
> 15 years past their original expiration date.
> In light of these results, a former director of the testing program, Francis 
> Flaherty, said he concluded that expiration dates put on by manufacturers 
> typically have no bearing on whether a drug is usable for longer. Mr.
> Flaherty 
> noted that a drug maker is required to prove only that a drug is still good
> on 
> whatever expiration date the company chooses to set. The expiration date
> doesn't 
> mean, or even suggest, that the drug will stop being effective after that, 
> nor that it will become harmful. "Manufacturers put expiration dates on for 
> marketing, rather than scientific, reasons," said Mr. Flaherty, a pharmacist
> at 
> the FDA until his retirement in 1999. "It's not profitable for them to have 
> products on a shelf for 10 years. They want turnover."
> The FDA cautioned there isn't enough evidence from the program, which is 
> weighted toward drugs used during combat, to conclude most drugs in
> consumers' 
> medicine cabinets are potent beyond the expiration date. Joel Davis, however,
> a 
> former FDA expiration-date compliance chief, said that with a handful of 
> exceptions -- notably nitroglycerin, insulin, and some liquid antibiotics --
> most 
> drugs are probably as durable as those the agency has tested for the
> military. 
> "Most drugs degrade very slowly," he said. "In all likelihood, you can take a
> product you have at home and keep it for many years, especially if it's in
> the 
> refrigerator." Consider aspirin. Bayer AG puts 2-year or 3-year dates on 
> aspirin and says that it should be discarded after that. However, Chris
> Allen, a 
> vice president at the Bayer unit that makes aspirin, said the dating is
> "pretty 
> conservative"; when Bayer has tested 4-year-old aspirin, it remained 100% 
> effective, he said. So why doesn't Bayer set a 4-year expiration date?
> Because the 
> company often changes packaging, and it undertakes "continuous improvement 
> programs," Mr. Allen said. Each change triggers a need for more
> expiration-date 
> testing, and testing each time for a 4-year life would be impractical. Bayer 
> has never tested aspirin beyond 4 years, Mr. Allen said. But Jens Carstensen 
> has. Dr. Carstensen, professor emeritus at the University of Wisconsin's 
> pharmacy school, who wrote what is considered the main text on drug
> stability, said, 
> "I did a study of different aspirins, and after 5 years, Bayer was still 
> excellent. Aspirin, if made correctly, is very stable.
> Okay, I concede. My mother-in-law was right, once again. And I was wrong, 
> once again, and with a wiseacre attitude to boot. Sorry mom. Now I think I'll
> take a swig of the 10-year dead package of Alka Seltzer in my medicine chest
> -- 
> to ease the nausea I'm feeling from calculating how many billions of dollars 
> the pharmaceutical industry bilks out of unknowing consumers every year who 
> discard perfectly good drugs and buy new ones because they trust the
> industry's 
> "expiration date labeling."
> Reprinted with permission of Redflagsdaily
> 2003
> Thomas A. M. Kramer, MD, Associate Professor of Psychiatry, University of 
> Chicago, Chicago, Illinois 
> Medscape General Medicine 5(3), 2003. © 2003 Medscape

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