Fw: Narcan injections for detox??? American Journal of Addiction.
ptpeet at nyc.rr.com
Tue Oct 28 18:08:38 EST 2003
Seems a bit barbaric to me.
----- Original Message -----
From: "Andrew Byrne" <ajbyrne at ozemail.com.au>
To: "Andrew Byrne" <ajbyrne at ozemail.com.au>
Sent: Tuesday, October 28, 2003 4:56 PM
Subject: Narcan injections for detox??? American Journal of Addiction.
> The Effectiveness of Combined Naloxone/Lofexidine in Opiate
> Detoxification: Results from a Double-blind Randomized and
> Placebo-controlled Trial. Beswick T, Best D, Bearn J, Gossop M, Rees S,
> Strang J. American Journal of Addiction (2003) 12;4:295-305
> Dear Colleagues,
> This intriguing trial from a London based group gave frequent injections
> of naloxone to addicts in a detoxification ward.
> The authors state that methadone ‘has been the standard treatment for
> in-patient opioid detoxification’. This may be the case in England but
> not necessarily elsewhere. There seems to be an assumption that
> lofexidine (and/or clonidine) are safe and effective in outcomes of
> opioid withdrawal episodes. Although there are apparently fewer
> hypotensive side effects with lofexidine (‘Brit-Lofex), a recent study
> from England, a generation of experience and the absence of a reported
> black market would seem to cast some doubt on their efficacy in
> successful heroin withdrawals. Next comes the rather controversial and
> little-researched use of naloxone in drug withdrawal. These researchers
> gave most subjects over 30 hypodermic injections, a behaviour which most
> of us are actively trying to discourage.
> After finding that there were no significant differences in overall
> outcomes in those randomised to receive the antagonist naloxone, the
> authors come to the surprising conclusion that more research is needed
> on this treatment modality for those trying to quit heroin. With the
> increasing use of buprenorphine for detoxification, it would seem almost
> outlandish to support the use of injectable, short acting antagonists
> like naloxone.
> About half of the 33 references are from the authors themselves which
> may indicate their pre-eminence in the field of opioid detoxification.
> Comments by Andrew Byrne ..
> Dr Andrew Byrne,
> Medical Practitioner, Drug and Alcohol,
> 75 Redfern Street, Redfern,
> New South Wales, 2016, Australia
> Email - ajbyrneATozemail.com.au
> Tel (61 - 2) 9319 5524 Fax 9318 0631
> My grandfather Harry Gracie's letters from 1924 trip to Mayo Clinic:
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