[ibogaine] recovery options and the concept of addiction
ross at cgl.ucsf.EDU
Fri Jul 12 19:08:40 EDT 2002
I've changed the topic because whether ibogaine alters
genetic expression could be a very interesting thread if
anyone who knew what they were talking about posted anything,
Now that you mention it :-)
Short-term regulation could come about by direct binding of ibo to
some nucleic acid or bound enzyme, in the simplest case. I wonder
if anyone has looked to see if ibo binds in such a place (if
they did & the result was negative, they might not publish, since
journals prefer positive results).
I wonder if any long-term change not involving ongoing drug ingestion,
diet or activity change, or genetic mutation might necessarily be due
to altered genetic expression? What else could cause the measured
balance of enzymes to shift? If serotonin levels are higher, presumably
the serotonin gene is getting expressed more, or the genes controlling
its uptake are expressed less, etc. I have the impression that some
people retain the mood changes of SSRI's after they stop taking them,
so possibly these drugs change genetic expression, and there may be
more data for them (not to mention other drugs unrelated to mood).
What drives me crazy is I don't understand. What did she ever
see in you when you were some strung out mess that landed on
her doorstep, threw a lit cigarette on her couch and told her
what a bitch she is. ...
If it's any consolation, you seem to be as smart and articulate
as Patrick, just not enjoying it as flamboyantly.
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