[ibogaine] Ibogaine Signals Addiction Genes

Carla Barnes carlambarnes at yahoo.com
Fri Jul 12 01:11:44 EDT 2002

That one guy who shows up with some questions every
couple of weeks and then leaves mentions that, quoting
the entheogen review article, saying that ibogaine
re-writes genetic expression. Patrick describes it as
hitting a reset on your brain and bringing you back to
a "pre addiction modality". So would this mean that
ibogaine is re-writing genetic expression back to what
it was prior to drug use, ibogaine is re-writing
genetic expression to something else completely,
ibogaine is re-writing genetic expression to what???

What does it mean exactly to "re-write" genetic

I don't want to sound dumb and if anyone has anything
I should read I will, I am realllllly curious. And if
it does all this isn't that just going to make the FDA
much more paranoid and crazy about it, instead of more

Carla B

--- HSLotsof at aol.com wrote:
>  Ann N Y Acad Sci 2002 Jun;965:28-46     
> Ibogaine Signals Addiction Genes and Methamphetamine
> Alteration of Long-Term 
> Potentiation.
> Onaivi ES, Ali SF, Chirwa SS, Zwiller J, Thiriet N,
> Akinshola BE, Ishiguro H.
> Department of Biology, William Paterson University,
> Wayne, New Jersey 07470, 
> USA.
> The mapping of the human genetic code will enable us
> to identify potential 
> gene products involved in human addictions and
> diseases that have hereditary 
> components. Thus, large-scale, parallel
> gene-expression studies, made 
> possible by advances in microarray technologies,
> have shown insights into the 
> connection between specific genes, or sets of genes,
> and human diseases. The 
> compulsive use of addictive substances despite
> adverse consequences continues 
> to affect society, and the science underlying these
> addictions in general is 
> intensively studied. Pharmacological treatment of
> drug and alcohol addiction 
> has largely been disappointing, and new therapeutic
> targets and hypotheses 
> are needed. As the usefulness of the pharmacotherapy
> of addiction has been 
> limited, an emerging potential, yet controversial,
> therapeutic agent is the 
> natural alkaloid ibogaine. We have continued to
> investigate programs of gene 
> expression and the putative signaling molecules used
> by psychostimulants such 
> as amphetamine in in vivo and in vitro models. Our
> work and that of others 
> reveal that complex but defined signal transduction
> pathways are associated 
> with psychostimulant administration and that there
> is broad-spectrum 
> regulation of these signals by ibogaine. We report
> that the actions of 
> methamphetamine were similar to those of cocaine,
> including the propensity to 
> alter long-term potentiation (LTP) in the
> hippocampus of the rat brain. This 
> action suggests that there may be a "threshold"
> beyond which the excessive 
> brain stimulation that probably occurs with
> compulsive psychostimulant use 
> results in the occlusion of LTP. The influence of
> ibogaine on immediate early 
> genes (IEGs) and other candidate genes possibly
> regulated by psychostimulants 
> and other abused substances requires further
> evaluation in compulsive use, 
> reward, relapse, tolerance, craving and withdrawal
> reactions. It is therefore 
> tempting to suggest that ibogaine signals addiction
> gene products.

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